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Chemelli et al (1999) examined fos-reactivity in orexin neurons of mice supplied modafinil prior to sacrifice and found a significantly larger activation of orexin neurons with modafinil than with placebo.modafinil will raise the stage or result of diazepam intranasal by impacting hepatic enzyme CYP2C19 metabolism. Use Caution/Monitor. Strong or mo… Read More

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Nonetheless, pretreatment with corticosterone or dexamethasone mitigated the impact of worry on modafinil’s motion outcomes. The authors remark that these results assistance the hypothesis that worry desensitizes or inhibits αone adrenoreceptors and corticosterone pretreatment attenuates this result, though the precise mechanism of the im… Read More